Integrative Therapeutics





Practical Dietary, Nutriceutical, & Environmental Strategies

in Support of Therapy for the Glaucomas 

Intraocular Pressure (IOP) Elevation Risk Factors

Benjamin Clarence Lane, OD


Pharmaceutical/surgical intervention can be deferred, reduced, or eliminated depending upon adequacy of response to reduction of the following risk factors

1. Daily repeated, long-sustained closework eye-focusing stimulus. {SEE: Lane BC: Elevation of Intraocular Pressure with Daily Sustained Reading and Closework Stimulus to Accommodation. Ann Arbor, MI: University Microfilms International (Publication #13-14,525), 1980.]  Preventive:   The precise closework eyeglass Rx suggested by functional testing.  Green lenses may be helpful [Zaretskaya RB: Am J Ophthalmol  1948; 31:721-7 & 985-9].

2. Inadequate Chromium (Cr) intake &/or excessive (XS) Cr loss  into urine associated with XS refined carbohydrate (CHO) intake. [This risk factor as indexed in red blood cells (RBCs) is the most significant differentiator between normals and persons with primary open-angle glaucoma (POAG)


POAG:    mean RBC Cr = 118.95 ng/ml Normals: mean RBC Cr =  279.25 ng/ml t = -3.183, p = 0.003


Persons with RBC Cr less than or equal to 150 ng/ml are 4.7 X more likely to have IOP elevated above 20 mm Hg than persons with greater concentrations of Cr in RBCs, Odds Ratio (OR) = 4.7, p=0.01 by Fisher’s Exact Test, Odds Ratio 95% Confidence Interval = 1.4—16.4.]  Preventive:  Food Cr is best available from whole foods high in energy content and some high-in-protein foods that can yield glucose by gluconeogenesis.  It is concentrated in the cream (butterfat fraction) in milk, the yolks of eggs, the molasses fraction of cane sugar——each presenting some new risks when consumed in the fractionated forms.  Red meat is rich in Cr, while chicken and turkey meats are high in Vanadium, the major antagonist to Cr.  Cr is concentrated in whole grains, but is largely lost from white-flour breads and cakes and from white rice.  Amino-acid chelated Cr is generally inadvertently tabletted with undeclared vanadium and is not recommended as a Cr supplement.  Recommendable Cr supplements (if testing indicates the need) include the following: Glucose-Tolerance-Factor (GTF-) Cr as made from “Chromax,” Cr Picolinate, or Cr Polynicotinate (“ChromeMate”). 

3. XS Vanadium-to-Chromium (V/Cr) intake ratio--commonly occurs when XS large fish & chicken in ratio to too little sweet fruits, sweet or starchy veggies and whole grains in absence of intake of whole eggs, whole milk.     [SEE: Lane BC: J Int Acad Prev Med 1982; 7(3=Nov):17-30, & Becker B: Proctor Lect., Invest Ophthalmol Vis Sci 1980; 19(10): 1156-65 as to topical vanadate.] Preventive: Avoid excessive intake of amino-acid chelated Cr, vanadium sources including kelp, dulse, seaweed, large marine fish (especially avoid shark, swordfish, tuna, but also even much smaller large fish, as well as fish from the Great Lakes because of toxicants.  Also avoid commercially fed chicken and poultry, large or frequent portions of mushrooms, and even vinegar, chocolate, and carob.

4. XS (processed, refined CHO)/(ascorbic acid) intakes. Preventive:  Avoid foods with supplemental white sugar, white flour, highly refined alcoholic beverages (especially gin, vodka).

5. XS (processed. refined CHO)/(food-folic acid)  intakes.  Preventive:  Food-folate intake can be enhanced by consuming more raw, fresh salad vegetables and fresh, ripe, raw fruits.  Folate is absolutely essential for synthesis of new cells, since it is essential for DNA and RNA synthesis.  Hence, it is most abundant in tissues that have the greatest potential for rapid growth, such as asparagus, spinach leaves, garbanzo beans, and bean sprouts.  Cooking tremendously reduces the folate content of most foods.
6. Inadequate aerobic conditioning, invalidism. [Cooper KH et al, Aerospace Med 1965; 36: 51-53.] Preventive: Ideally, at least 45 minutes of virtually non-stop strolling/walking or substitute aerobic activity and duration on alternate days.
7. Early  evidence for diet-related pigmentary-syndromes risk factors:
Likely DEPRESSED erythrocyte superoxide dismutase (ESOD), catalase/RBC, plasma eicosapentaenoic acid (EPA). [SEE: Bito LZ: Glaucoma: Applied Pharmacology in Medical Treatment. Grune&Stratton, 1984, as to eicosanoids; Kulkarni & Srinivasan: Prog Clin Biol Res 1989; 312: 39-52, as to EPA, omega-3 fatty acids, prostaglandin synthase.] Likely ELEVATED  individual long-chain Fatty Acids, trans FAs, EGOT or EGPT, d-Glucaric Acid, XS protein intake >> 2x RDA.  Preventive: Correction of copper and/or zinc deficiencies as suggested by testing.  Avoidance of excessive intake of “well-cooked” high-in-protein foods (incl meats, fish, tofu) and of excessive protein in general.  Peeling of fruit skins and/or washing with Rokeach Kitchen Soap or 1/2 teaspoon of Clorox in a gallon of water for washing fruits and vegetables and rinsing well thereafter.

8. Narrow-Angle Glaucoma “environmental” risk factors:

a) Darkness. Preventive:  Two or three night lights in the bedroom to avoid complete darkness.

(b) Pharmaceuticals: Inadequate cautions & mislabelling. Avoid medications with glaucoma warnings.

9. The issue of “scleral-non-expansion glaucoma” versus “scleral-expansion glaucoma” (myopia) [See: Thomas Stuart-Black Kelly, MD, 3rd Intl Conf on Myopia, Doc Ophthalmologica Proc Ser 1981; vol 28, 109-116.

10. The issue of “scleral-non-expansion glaucoma” versus “scleral-expansion glaucoma” (myopia) [See: Thomas Stuart-Black Kelly, MD, 3rd Intl Conf on Myopia, Doc Ophthalmologica Proc Ser 1981; vol 28, 109-116.


Persons considering “prudent” modification of diet regimens or environmental interactions so as to reduce risks for ocular hypertension should continue with their regularly scheduled eye-doctor visits and with medications and therapies until their eye doctor finds that they may or should be modified.



Lane B.C.

“Diet-responsive biochemical markers for ocular hypertension in primary open-angle glaucoma.”  Investigative Ophthalmology & Visual Science 1996; 37(3=Feb 15): S815, abstract.

Lane B.C.

“Nutrition and Vision” in J Bland, ed., First Edition: 1984-’85 Yearbook of Nutritional Medicine. New Canaan, CT: Keats Publishing, 1985, pages 239-281.

Lane B.C.

“Elevation of intraocular pressure with daily sustained closework stimulus to accommodation, lowered tissue chromium, and dietary deficiency of ascorbic acid (vitamin C)” in  HC Fledelius, PH Alsbirk, and E Goldschmidt, eds.,  Documenta Ophthalmologica Proceedings Series 1981; vol 28: 149-155.  The Hague, Holland: Dr W. Junk Publishers.

Lane B.C.

Myopia prevention and reversal:  New data confirms the interaction of accommodative stress and deficit-inducing nutrition.”  Journal of the International Academy of Preventive Medicine 1982; 7(3=Nov), 17-30.

Lane B.C.

Elevation of Intraocular Pressure with Daily, Sustained Reading & Closework Stimulus to Accommodation Ann Arbor, MI: University Microfilms International: Publication #13-14,525; 1980.

“In the Vanguard of Dietary Research and Integrative Therapy in the Prevention and Reversal of Eye and Vision Disorders”

jordan 6 sport blue sport blue 6s new jordans 2014 retro jordans for sale louis vuitton outlet louis vuitton outlet louis vuitton outlet michael kors outlet louis vuitton outlet michael kors outlet sport blue 3s coach factory outlet jordan 3 sport blue cheap jordans louis vuitton outlet sport blue 3s michael kors outlet jordan 3 sport blue sport blue 3s sport blue 6s